Josh Nagel has his finger on the pulse of Geno Smith, Tyler Lockett, DK Metcalf and the Seattle Seahawks.
[See which team to pick here](https://www.sportsline.com/insiders/nfl-week-15-49ers-vs-seahawks-line-odds-seattle-expert-reveals-spread-pick-for-thursday-night-football-game/#ttag=12142022_agg_cbssports_picks_football_nfl_joshnagel_Seahawks49ersTNFexpert). [Sam Darnold](/nfl/players/2180320/sam-darnold/) last week. [Visit SportsLine now to see which side of the 49ers vs. [You can head to SportsLine to see Nagel's picks](https://www.sportsline.com/insiders/nfl-week-15-49ers-vs-seahawks-line-odds-seattle-expert-reveals-spread-pick-for-thursday-night-football-game/#ttag=12142022_agg_cbssports_picks_football_nfl_joshnagel_Seahawks49ersTNFexpert). 49ers](https://www.sportsline.com/nfl/game-forecast/NFL_20221215_SF@SEA/) and just locked in his picks and TNF predictions. Lockett has scored a touchdown in the last six games, the longest streak in franchise history. The 49ers are averaging 6.45 yards after the catch this season, which ranks third in the league. Now, here are several [ NFL odds](https://www.sportsline.com/nfl/odds) and betting lines for Niners. [Seattle Seahawks](https://www.cbssports.com/nfl/teams/SEA/seattle-seahawks/) will try to stay alive in the NFC West title race when they host the rival [San Francisco 49ers](https://www.cbssports.com/nfl/teams/SF/san-francisco-49ers/) on Thursday Night Football. vs. San Francisco is a three-point favorite in the latest Seahawks vs. 49ers odds from Caesars Sportsbook, while the over/under for total points scored is 43.
In Brock Purdy's debut as the Niners, he looked like the best quarterback on the field in a game in which he went up against Tom Brady and the Buccaneers.
Hello everyone and welcome to Seattle where the Seahawks are looking to put an end to a late season slump that has their playoff chances hanging on the edge. The San Francisco 49ers travel to Seattle to take on the Seahawks looking to clinch the division against their bitter rivals on their home turf. In Brock Purdy’s debut as the Niners, he looked like the best quarterback on the field in a game in which he went up against Tom Brady and the Buccaneers. Most of that came in the first half as the Niners defense shut down the Bucs offense and the game was a blow out by the time halftime came around. At the moment they are on the outside looking in, sitting right behind the Giants and the Commanders in 6th and 7th. Maybe Pete Carroll’s men were looking at the their divisional game too soon and didn’t focus on the Panthers enough. They have been so good at home over the last decade, but they have lost two straight at Lumen Field and need to turn the tables on this recent skid at home. The pressure came quick and Smith had to get rid of it before the sack came. And they get the ball back to start the third quarter. Brock Purdue is only a few months removed from being the final pick in the NFL draft. SEA big man Mone was hurt on the play, more to come on his status. What a play call from Kyle Shanahan to get Kittle wide open down the middle.
The Sporting News is tracking all the key moments as San Francisco and Seattle clash on "Thursday Night Football."
ET (5:15 p.m. - Time: 8:15 p.m. The game will kick off at 8:15 p.m. On 4th and 7, the Niners hustle up to the line as the quarter winds down to try and get Seattle to jump offside — and it works. — Purdy finally misses on a short pass to McCaffrey to ruin his perfect night and bring up 3rd and 9. — After a shot to the end zone gets deflected for an incompletion, it brings up 3rd and 8. He plows forward to convert on 3rd and 1 and bring his tally up to 82 total yards on the night. — Purdy makes one of his first mistakes of the night, and it nearly results in a pick. But on 3rd and 4, Geno throws it short of the sticks to Walker and he can't even pick up the first down. — Lockett comes up with a grab on 3rd and 4 to move the Seahawks close to the edge of the red zone. The officials first ruled it incomplete, then changed the call on the field to a completion. After two McCaffrey carries up the middle, San Francisco faces a 3rd and 2 to try and seal the win — and the division crown.
Nick Bosa and Co. paved the way for the 49ers' division-clinching victory over the Seattle Seahawks on Thursday night.
Purdy did get away with a few passes late in the first half, throwing what should have been an interception right into the chest of the Seahawks’ [Quandre Diggs](https://www.nfl.com/players/quandre-diggs/)late in the second quarter. He took some absolute shots against the 49ers and was still trying to coax his teammates to mount a late fight, which they did. The highlight was a Purdy beauty on the touchdown pass to [George Kittle](https://www.nfl.com/players/george-kittle/), faking two screens before firing the ball on a delay route to the open tight end, who did the rest of the work on the 28-yard score. While the Seahawks’ defense largely did what it needed to do to keep them in the game, the offense came up short with a pair of field goals. A lot of forces were working against Smith against the 49ers, and let’s be honest: These issues have been brewing for a while. [Brock Purdy](https://www.nfl.com/players/brock-purdy/)passes another test for NFC West-winning 49ers.
But how long Purdy would be able to play through his oblique injury lingered all night in the mind of San Francisco coach Kyle Shanahan. “We were going to see ...
[Robbie Gould](http://www.espn.com/nfl/player/_/id/9354/robbie-gould) missed a 43-yard field goal and the Seahawks went 67 yards in 1:25. But man, I just hate losing and gotta figure it out,” Smith said. Purdy finished 17 of 26 for 217 yards, joining “Whenever Kyle dials something up that you know you’re gonna get the ball, you try to speak it into existence. “But he just got comfortable and got better as the game went on. That was that,” Purdy said.
Follow live scores and updates, as the San fransisco 49ers face the Seattle Seahawks. Tweets from NFL.
Brock Purdy got the job done once again. Purdy led the San Francisco 49ers to a solid 21-13 win over the Seattle Seahawks at Lumen Field in just his second ...