Multiple sclerosis

2022 - 11 - 1

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Image courtesy of "Globalnews.ca"

Christina Applegate details multiple sclerosis progression: 'I'm never ... (Globalnews.ca)

The Emmy-winning actor revealed her MS diagnosis last year; MS is a degenerative autoimmune disease that impacts the brain and spinal cord. There is a myriad of ...

For Applegate, filming the new season of Dead to Me — a dramedy in which she plays Jen, a widowed real estate agent — was no easy feat. On average, the organization states, 12 Canadians are diagnosed with MS every day, with most diagnosed between the ages of 20 and 49. She had difficulty walking down the stairs of her trailer and had to often use a wheelchair on set. There is a myriad of symptoms, from muscle stiffness to vertigo and bladder issues. “It’s been a strange journey. I want people to know that I am very aware of all of that.”

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Image courtesy of "Healthline"

Multiple Sclerosis (MS): How Weight and BMI at the Time of ... (Healthline)

According to a new study, people who are overweight at the time of a multiple sclerosis (MS) diagnosis have an increased risk of disability and more severe ...

“My clients with MS are more motivated to feel better than to lose a few pounds. However, we often uncover that they struggle with severe fatigue, symptoms of [burn-out](/health-news/how-burnout-at-work-may-be-causing-you-to-gain-weight), and big energy swings that affect their quality of life.” In that case, your doctor might suggest you see a dietician to help you work on the best foods to eat or whether you could benefit from supplementing your food with nutrients, such as protein. “For example, someone with a larger amount of muscle could have a high BMI that is not due to fatty tissue. [steroids](/health/steroids-for-ms), can cause you to gain weight. [Caroline Thomason](http://www.carolinethomason.com/), RD, CDCES, a dietician who specializes in helping women stop dieting and feel better. BMI is also not as accurate for some people, such as people of color. Obesity, the researchers indicated, is a modifiable risk factor. “A healthy diet has benefits beyond MS, improving general heart and brain health,” Sy told Healthline. [Michael Sy](https://www.ucihealth.org/find-a-doctor/s/michael-y-sy), MD, Ph.D., a neurologist with UCI Health in Irvine, CA. The average age of participants was 33, and about 30 percent were male. [relapsing/remitting MS](/health/multiple-sclerosis) in Germany who participated in The German National MS Study.

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Image courtesy of "Us Weekly"

Christina Applegate Details Gaining 40 Lbs, Not Being Able to 'Walk ... (Us Weekly)

Christina Applegate said that she's 'never going to accept' how her life has changed since her multiple sclerosis diagnosis — read more.

[but she pressed on](https://www.usmagazine.com/celebrity-news/news/christina-applegate-finished-filming-dead-to-me-amid-ms-battle/). [evealed her multiple sclerosis battle](https://www.usmagazine.com/celebrity-news/news/christina-applegate-announces-multiple-sclerosis-diagnosis/) in August 2021, explaining that she’d been diagnosed “a few months” prior. “And I have MS. I needed to process my loss of my life, my loss of that part of me. Though she’s worked to “process” her diagnosis, she noted that she’s not ready to “accept” how her life has changed. “I had an obligation to [creator] Liz [Feldman] and to [costar] [Linda [Cardellini]](https://www.usmagazine.com/celebrities/linda-cardellini/), to our story.” But I try.” “I have a very important ceremony coming up,” she “It’s not like I came on the other side of it, like, ‘Woohoo, I’m totally fine,’” she told the outlet. “It’s been a strange journey,” she tweeted at the time. [tweeted](https://twitter.com/1capplegate/status/1585669557024264192) on Thursday, October 27, alongside a photo of several walking sticks. “I put on 40 pounds; I can’t walk without a cane.

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Image courtesy of "Yahoo! Voices"

Christina Applegate recalls symptoms of multiple sclerosis she ... (Yahoo! Voices)

Actor, who was diagnosed with autoimmune disease in 2021, says: 'I wish I had paid attention'

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Image courtesy of "UPI.com"

Multiple sclerosis may rapidly worsen in patients who are obese (UPI.com)

Obesity is never healthy, and that may be especially true for people who also develop multiple sclerosis.

"We do not precisely understand the pathophysiology of this," he said. Patients who were overweight but not obese did not face a higher risk of disability. And their levels of disability grew faster than those of people who weren't obese, the researchers found. Obese patients reached a higher level on the Expanded Disability Status Scale in just under 12 months, compared with nearly 18 months for those who weren't obese. "The treatment of MS is not solely about disease-modifying agents. The researchers collected data on 1,066 patients with "What has not been clear is how obesity is linked to disease severity and disability progression in individuals with MS. [elevated BMI](https://www.cdc.gov/obesity/basics/adult-defining.html#:~:text=Adult%20Body%20Mass%20Index&text=If%20your%20BMI%20is%20less,falls%20within%20the%20obesity%20range.) (body mass index) on mechanisms that drive neurologic disability in MS," said Dr. [autoimmune disease](https://medlineplus.gov/autoimmunediseases.html) that affects the central nervous system. Asaff Harel, director of the multiple sclerosis center at Lenox Hill Hospital in New York City. He played no role in the research. It can cause permanent disability or even death, and there is no cure.

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Image courtesy of "Yahoo Lifestyle UK"

Christina Applegate shares health struggles following multiple ... (Yahoo Lifestyle UK)

The actor shared her multiple sclerosis diagnosis in August 2021 and has now opened up about the impact of living with the condition.

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How Christina Applegate's Multiple Sclerosis Impacted Filming ... (Shape Magazine)

Christina Applegate opened up about the challenges of filming the final season of her Netflix series "Dead to Me" after being diagnosed with multiple ...

"She [Cardellini] was my champion, my warrior, my voice," said Applegate. "'We’re going to do it, but we’re going to do it on my terms.’” I needed to process my loss of my life, my loss of that part of me. When people suggested they put a stop to filming the final season of Dead to Me, Applegate insisted they continue. She felt off balance while filming a dance scene for the first season of Dead to Me, and she noticed her tennis skills were declining. "But who was I to know?"

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Image courtesy of "Scary Mommy"

Christina Applegate's Multiple Sclerosis Diagnosis Felt Like The ... (Scary Mommy)

But now that filming has wrapped and new episodes are set to debut Nov. 17, she wants to make people aware of her health battle as, “this is the first time ...

We’re going to do it, but we’re going to do it on my terms.’” [battled breast cancer](https://www.cnn.com/2008/LIVING/10/14/o.christina.applegate.double.mastectomy/) and had a double mastectomy in 2008 — first shared news of her [diagnosis](https://www.scarymommy.com/christina-applegate-multiple-sclerosis-diagnosis) on Twitter in Aug. I needed to process my loss of my life, my loss of that part of me. Unless some asshole blocks it,” Applegate wrote, in part, with her The Sweetest Thing co-star Blair commenting, "Loving you always. “But who was I to know?” “I’m sure that people are going to be, like, ‘I can’t get past it.’ Fine, don’t get past it, then,” she continued. Cohn would be out of the camera’s range, on the floor, holding up her legs. But as we all know, the road keeps going. Some changes were made to scene blocking to hide any balance issues, but the script was kept intact. She felt off balance, and her tennis game was faltering. But now that filming has wrapped and new episodes are set to debut Nov. “I put on 40 pounds; I can’t walk without a cane.

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Image courtesy of "HealthDay"

Obesity Linked to Greater Disability, Poorer Outcomes in MS (HealthDay)

Patients with obesity had significantly increased risk for reaching EDSS 3 over six years, independent of disease-modifying therapies.

The median time to reach EDSS 3 was 0.99 and 1.46 years for patients with and without obesity, respectively. Isabel Lutfullin, from the University Hospital Münster in Germany, and colleagues conducted a nationwide, longitudinal cohort study with 1,066 individuals with newly diagnosed MS to examine the association between obesity and disability accumulation. 2, 2022 (HealthDay News) -- For newly diagnosed patients with multiple sclerosis (MS), obesity is associated with higher disease severity and poorer outcomes, according to a study published online Nov.

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Image courtesy of "Yahoo News"

Christina Applegate shares health struggles following multiple ... (Yahoo News)

The actor shared her multiple sclerosis diagnosis in August 2021 and has now opened up about the impact of living with the condition.

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Image courtesy of "Goss.ie"

Christina Applegate opens up about her recent multiple sclerosis ... (Goss.ie)

The award-winning actress was diagnosed with MS last summer while in the middle of filming the final season of Netflix's Dead to Me. Her diagnosis halted ...

I needed to process my loss of my life, my loss of that part of me. So I needed that time.” But who was I to know?”

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Image courtesy of "Tyler Morning Telegraph"

Obesity Linked to Greater Disability, Poorer Outcomes in MS (Tyler Morning Telegraph)

WEDNESDAY, Nov. 2, 2022 (HealthDay News) -- For newly diagnosed patients with multiple sclerosis (MS), obesity is associated with higher disease severity ...

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Image courtesy of "NBC News"

Christina Applegate on the subtle signs that led to MS diagnosis: 'I ... (NBC News)

Christina Applegate is opening up about the early physical symptoms in her body that led to her being diagnosed with multiple sclerosis.

Applegate calls filming the final season of “Dead To Me,” which premieres Nov. Walking sticks are now part of my new normal,” she wrote alongside the pic. I needed to process my loss of my life, my loss of that part of me. “But who was I to know?” The former “Married ... “Acceptance?

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Image courtesy of "The Independent"

Christina Applegate recalls symptoms of multiple sclerosis she ... (The Independent)

Actor, who was diagnosed with autoimmune disease in 2021, says: 'I wish I had paid attention'

In November, the actor celebrated her 50th birthday while acknowledging that it had been a “hard one”. I needed to process my loss of my life, my loss of that part of me. Although production of the show halted, Applegate eventually returned to set to finish the show. According to Applegate, who said finishing the series was the hardest thing she’s ever done, there were also times a crew member and friend members would be holding her legs up out of the camera’s range. “I’m sure that people are going to be, like: ‘I can’t get past it.’ Following the diagnosis, production of Dead to Me was paused as the actor began treatment. Walking sticks are now part of my new normal,” she But I have been so supported by people that I know who also have this condition.” The disease can also affect balance, and cause “tremors, lack of coordination, or unsteady gait”. “But who was I to know?” She was diagnosed with MS in the summer of 2021. The actor said she then found herself struggling to play tennis.

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Image courtesy of "Yahoo News"

Christina Applegate recalls symptoms of multiple sclerosis she ... (Yahoo News)

Actor, who was diagnosed with autoimmune disease in 2021, says: 'I wish I had paid attention'

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Obesity at MS diagnosis linked to higher levels of disability | BMJ (The BMJ)

Reverting to a healthy weight may improve clinical outcomes for obese patients with MS, suggest the researchers. Obesity during childhood and adolescence is ...

But levels of disability were higher at the time of diagnosis and at each of the subsequent three time points, after factoring in age, sex, and smoking. And the average time it took obese patients to accumulate greater levels of disability was shorter. When MS was diagnosed, 159 patients (15%) were obese with a BMI of at least 30. More than a quarter (29.5%, 315) of them were men with an average age of 33. This is an observational study, and as such, can’t establish cause. Obesity at MS diagnosis linked to higher current and subsequent levels of disability

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