Rams vs 49ers

Matthew Stafford and the Rams have struggled to breakthrough on offense this season, and the San Francisco 49ers will provide a significant test.

It's always a fun time when the Rams and 49ers link up. Here's how to watch the "Monday Night Football" matchup between the NFC West rivals.

NFL odds, picks and predictions for Los Angeles Rams vs San Francisco 49ers. NFL betting best bet and game analysis.

If you're looking to watch this divisional game online without cable, The Sporting News has you covered with streaming information below.

The San Francisco 49ers are without seven players for "Monday Night Football" against the Los Angeles Rams.

SportsLine simulated San Francisco 49ers vs. Los Angeles Rams on Monday Night Football 10000 times and made its best bets.

Here are the [NFL odds](https://www.sportsline.com/nfl/odds/) and betting lines for Rams vs. [Jalen Ramsey](/nfl/players/2071515/jalen-ramsey/) and defensive lineman [Aaron Donald](/nfl/players/1737460/aaron-donald/) leading the defensive unit. [Visit SportsLine right now to find out which side of the 49ers vs. He's first on the team in sacks (4) and tackles for loss (4) with 11 total tackles. [You can head to SportsLine now to see the model's picks](https://www.sportsline.com/insiders/rams-vs-49ers-nfl-week-4-lines-odds-picks-monday-night-football-predictions-and-best-bets-from-proven-model/#ttag=10012022_agg_cbssports_picks_football_nfl_model_rams49ersMNFmodel). Rams](https://www.sportsline.com/nfl/game-forecast/NFL_20221003_LAR@SF/) matchup and just locked in its picks and MNF predictions. The model also says one side of the spread hits well over 50% of the time. [Fred Warner](/nfl/players/2142098/fred-warner/) is a fast playmaker who runs sideline to sideline. [San Francisco 49ers](https://www.cbssports.com/nfl/teams/SF/san-francisco-49ers/) (1-2) hosting the [Los Angeles Rams](https://www.cbssports.com/nfl/teams/LAR/los-angeles-rams/) (2-1). The model enters Week 4 of the 2022 NFL season on an incredible 139-103 run on top-rated [NFL picks](/nfl/picks/experts) that dates back to the 2017 season. San Francisco is favored by two points in the latest Rams vs. 49ers odds from Caesars Sportsbook, and the over/under is 42.5.

The Sporting News tracked live updates and highlights from Rams vs. 49ers. Below are the results as they happened on Monday night.

Matthew Stafford leading the Rams on the field. 8:05 p.m.: Jerry Rice is in the house! 57 yards to the house in the blink of an eye. 9:06 p.m.: Another snag for tight end Tyler Higbee, his fifth of the game. 10:07 p.m.: The first play of the drive is a big one! Cam Akers skips through the tackles to get a handful of yards, good enough to move the chains on fourth down. That's one way to limit the effectiveness of the passing game. 10:00 p.m.: Kupp finds space behind the tackles on a screen play, gaining 14 yards in the process. However, it falls into the path of a 49ers player. The Rams have a little over eight minutes to mount a comeback. 10:10 p.m.: Juz with another impressive play, taking a handoff misdirection and juking outside the tackles for the first. That's the Niners fifth sack of the night.

The LA Rams vs. the San Francisco 49ers: Here is all of the Game day info, betting spread, and how to watch information that you need to enjoy the game.

The 2022 NFL regular season is in full swing, and it's an NFC West battle in Week 4. The San Francisco 49ers (-4.5). Wager $10 on SF. To Beat CAR:$14.65.

We break down betting splits Week 4's Monday Night Football matchup featuring the Rams and 49ers.

The 49ers will have DL Arik Armstead on Monday Night Football, but Javon Kinlaw will not suit up.

In Rams vs 49ers MNF injury report, Los Angeles is missing 2 OL starters. Both of San Francisco's starting DT are questionable. Rams vs 49ers injury report.

Follow along with RamDigest.com as we keep you up to date with all firings, hirings, and breaking news in the NFL.

The Los Angeles Rams and San Francisco 49ers clash for a NFC West showdown on Monday Night Football.

San Francisco's defense continued it's strong start to the half by forced a second straight three-and-out. TOUCHDOWN NINERS: But all the Niners needed was one big play to break it open, as running back Jeff Wilson Jr. change of possession Stafford begins the opening drive with three completions to receiver Cooper Kupp, who total 27 yards. The Rams had lost seven of the last 10 - including six in a row dating back to 2019 - before last season's win in the conference championship. The Rams receive the opening kickoff and will begin at their own 25-yard line. It's a game that we're playing." "Every game in the NFL is a big one. "It feels like a big one," Stafford said.

The fan with the pink smoke bomb probably did not expect to get leveled by an NFL linebacker.

[Seattle Seahawks](https://www.cbssports.com/nfl/teams/SEA/seattle-seahawks/) legend, is in his first season with the Rams. [pic.twitter.com/nkDbzhSwcr] [October 4, 2022] And sometimes, they will turn their focus to the fans interrupting their game.