Rams

on Monday Night Football. The 49ers will be desperate for a win, in an attempt to avoid dropping to 1-3 on the season.

SportsLine simulated San Francisco 49ers vs. Los Angeles Rams on Monday Night Football 10000 times and made its best bets.

Here are the [NFL odds](https://www.sportsline.com/nfl/odds/) and betting lines for Rams vs. [Jalen Ramsey](/nfl/players/2071515/jalen-ramsey/) and defensive lineman [Aaron Donald](/nfl/players/1737460/aaron-donald/) leading the defensive unit. [Visit SportsLine right now to find out which side of the 49ers vs. He's first on the team in sacks (4) and tackles for loss (4) with 11 total tackles. [You can head to SportsLine now to see the model's picks](https://www.sportsline.com/insiders/rams-vs-49ers-nfl-week-4-lines-odds-picks-monday-night-football-predictions-and-best-bets-from-proven-model/#ttag=10012022_agg_cbssports_picks_football_nfl_model_rams49ersMNFmodel). Rams](https://www.sportsline.com/nfl/game-forecast/NFL_20221003_LAR@SF/) matchup and just locked in its picks and MNF predictions. The model also says one side of the spread hits well over 50% of the time. [Fred Warner](/nfl/players/2142098/fred-warner/) is a fast playmaker who runs sideline to sideline. [San Francisco 49ers](https://www.cbssports.com/nfl/teams/SF/san-francisco-49ers/) (1-2) hosting the [Los Angeles Rams](https://www.cbssports.com/nfl/teams/LAR/los-angeles-rams/) (2-1). The model enters Week 4 of the 2022 NFL season on an incredible 139-103 run on top-rated [NFL picks](/nfl/picks/experts) that dates back to the 2017 season. San Francisco is favored by two points in the latest Rams vs. 49ers odds from Caesars Sportsbook, and the over/under is 42.5.

The 49ers lost to the Rams in last year's NFC Championship, but oddsmakers expect a different result when they meet again in Week 4.

San Francisco’s vaunted defense, which ranks first in yards allowed (227) and points allowed (12.3) per game, is also beset by injuries. The results have been as expected: he ranks 29th in yards per game (182.5) and 30th in QBR (27.2) and has done very little to elevate the talent around him. In fact, if you took away that Week 1 clunker, he would rank sixth in passer rating (101.9) and third in yards per attempt (8.54). This team has looked listless outside of that game, scoring just 10 points in each of its other two contests with Week 1 backup Jimmy Garoppolo at the helm. If both teams were at full strength, perhaps this would be a different story. The Rams are undefeated since that loss, and Stafford still ranks second in the entire league in completion rate (72.5%). It’s easy to dismiss Los Angeles after that season-opening Thursday night loss at home, when millions watched the defending champions look entirely outclassed by the title favorite Bills. They aren’t, though, and I’d have a tough time banking on Garoppolo as a home favorite without more help around him. In recent years, this matchup has been dominated by the 49ers, who have won six straight regular-season contests against their division rivals. [best sports betting sites](https://www.inquirer.com/sports/betting/sportsbooks/best-sports-betting-sites.html) And oddsmakers are expecting another tight one Monday. [BetMGM Promo Code](https://www.inquirer.com/sports/betting/betmgm-welcome-offer.html)

Week 4 of the NFL season comes to a close with the Rams battling the 49ers on Monday Night Football. Here are the top plays!

The San Francisco 49ers are without seven players for "Monday Night Football" against the Los Angeles Rams.

The Los Angeles Rams had to make some tough decisions in selecting which players would be inactive for their primetime matchup against the San Francisco ...