Louisville started the 2022 season with a disappointing loss at Syracuse last week. Will the Cards be able to rebound today against UCF?
[Read more on Lole's injury here](https://www.courier-journal.com/story/sports/college/louisville/2022/09/09/louisville-football-defensive-lineman-jermayne-lole-out-for-season/68340745007/). [Jacksonโs self-imposed deadline](https://www.courier-journal.com/story/sports/nfl/columnist/mike-jones/2022/09/09/lamar-jackson-playing-long-game-ravens-new-contract/8023194001/) of Friday, the quarterback and Baltimore officials have agreed to hit the pause button on negotiations and will resume talks after the season so Jackson, who has represented himself rather than use an agent, can focus on playing. [Tiyon Evans](https://gocards.com/sports/football/roster/tiyon-evans/12771) 7-yard rushing touchdown. [Malik Cunningham breaks Louisville football record] [Malik Cunningham](https://gocards.com/sports/football/roster/malik-cunningham/12701) set a school record on his first snap Friday night against the University of Central Florida. [who announced his commitment to the Cardinals in May](https://www.courier-journal.com/story/sports/college/louisville/2022/05/20/jermayne-lole-louisville-football-recruiting-arizona-state-transfer/9861713002/), is out for the season with an elbow injury, a Louisville spokesperson confirmed Friday evening before U of L took on the University of Central Florida. [Malik Cunningham](https://www.courier-journal.com/story/sports/college/louisville/2022/09/10/louisville-football-qb-malik-cunningham-breaks-starts-record/68430734007/) passed for 201 yards (14 for 29) and ran for 121 yards (17 carries). [Tiyon Evans limps off field for Louisville] [Tiyon Evans](https://www.courier-journal.com/story/sports/college/louisville/2022/08/16/louisville-running-back-tiyon-evans-balances-football-fatherhood/65393828007/), the Louisville running back, limped off the field earlier in the second quarter. [Louisville fumbles, turns it over to UCF - 10:52, Q2] [Tiyon Evans](https://gocards.com/sports/football/roster/tiyon-evans/12771) ran 22 yards but was stripped by [Quadric Bullard](https://admin.ucfknights.com/sports/football/roster/quadric-bullard/13208). [Jalen Mitchell](https://gocards.com/sports/football/roster/jalen-mitchell/12741) is in at running back for U of L. [Malik Cunningham](https://gocards.com/sports/football/roster/malik-cunningham/12701) is still perfect through the air, going five for five and 86 yards. [UCF leads Louisville football at halftime - UCF 14, Louisville 7] Cunningham now has 176 passing yards (11 for 21) and 106 rushing yards (13 carries).
SportsLine's model just revealed its CFB picks and predictions for Louisville vs. UCF on Friday, September 9.
Fellow junior [Tyler Hudson](/college-football/players/3122893/tyler-hudson/), a wideout who spent the previous three years at [Central Arkansas](https://www.cbssports.com/college-football/teams/CAR/central-arkansas-bears/), also impressed as he made eight catches for 102 yards to become the fourth player in school history to reach triple digits in receiving yards in his first game with the Cardinals. [John Rhys Plumlee](/college-football/players/3126959/john-rhys-plumlee/), who threw for four and ran for another in his UCF debut. [Visit SportsLine now to see which side of the Louisville vs. A transfer from [Ole Miss](https://www.cbssports.com/college-football/teams/MISS/ole-miss-rebels/) when spent last season as a wide receiver, Plumlee completed 20-of-31 pass attempts for 308 yards and gained a team-high 86 yards on the ground. Here are several [college football odds](https://www.sportsline.com/college-football/odds/) and betting lines for Louisville vs. Louisville](https://www.sportsline.com/college-football/game-forecast/NCAAF_20220909_LVILLE@UCF/) and just revealed its picks and CFB predictions. UCF (1-0) continued its home success with a 56-10 triumph over [South Carolina State](https://www.cbssports.com/college-football/teams/SCST/south-carolina-state-bulldogs/) in its 2022 season opener, while Louisville (0-1) began the year with a 31-7 loss at [Syracuse](https://www.cbssports.com/college-football/teams/CUSE/syracuse-orange/). [You can visit SportsLine now to see the model's picks](https://www.sportsline.com/insiders/ucf-vs-louisville-college-football-odds-picks-advanced-computer-model-reveals-picks-for-fridays-matchup/#ttag=09062022_agg_cbssports_picks_football_ncaa_model_UCFLouisvilleCFB). Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated [college football picks](https://www.sportsline.com/college-football/picks/) against the spread. The Knights are 5.5-point favorites in the latest UCF vs. The Knights are well on their way to posting another incredible point total over their first two contests of the season. The Knights attempt to improve that mark when they host the [Louisville Cardinals](https://www.cbssports.com/college-football/teams/LVILLE/louisville-cardinals/) on Friday.
The Cardinals head down to the Sunshine State in an effort to rebound against the Knights.
[Scott Satterfield, Louisville Coordinators Recap Syracuse, Preview UCF](https://www.si.com/college/louisville/football/satterfield-coordinators-preview-ucf-2022) [Tyler Hudson, Ben Perry Recap Syracuse, Preview UCF](https://www.si.com/college/louisville/football/hudson-perry-preview-ucf-2022) [Louisville Working to Fix Energy and Effort Deficiency Ahead of UCF](https://www.si.com/college/louisville/football/increase-energy-effort-output) [Louisville 'Disappointed' with 'Disheartening' Tackling Issues vs. - Having started the program in 1979 and only having been playing at the FBS level since 1996, UCF became the youngest program by 35 years to win a New Yearโs Six/BCS bowl game when the Knights defeated Baylor in the 2014 Fiesta Bowl. He then recovered the punt in the endzone for the first punt returned for a touchdown for UCF since Nov. - Making his debut in a UCF uniform, quarterback John Rhys Plumlee wowed Knights fans with a stellar performance as he finished the night 20-of-31 passing for 308 yards and four touchdowns. Since 2017, the Knights are 31-2 in home games at FBC Mortgage Stadium. - UCF has accumulated a record of 48-12 in its last 60 games. [Tale of the Tape, Predictions: Louisville vs. - The Knights offense was equally as impressive, compiling 605 yards of total offense. Additionally, the 56 passing yards allowed rank fourth in the NCAA and the 35 rushing yards allowed ranks 10th nationally. - The Cardinals dropped their season and conference opener 31-7 to Syracuse last Saturday night in the JMA Wireless Dome. Louisville is making its first trip to Florida since defeating Florida State last season in Tallahassee. His 30-game streak of compiling at least one rushing or passing touchdown in a game came to an end.
UCF as less than a touchdown favorite against Louisville is too good of a bet to pass up on.
[BetMGM](https://nypost.com/article/betmgm-sign-up-offer/)). ET on ESPN2) The good news for Louisville fans is college basketball practice starts in a few weeks.
The 1-0 UCF Knights face the 0-1 Louisville Cardinals on Friday, September 9, 2022 in Orlando. Follow along for live updates.
There are no changes to the Knights' depth chart from their 56-10 opening victory over South Carolina State.] [As for Louisville, 247Sports reported that senior nose tackle ] [Jermayne Lole](https://www.courier-journal.com/story/sports/college/louisville/2022/09/09/louisville-football-defensive-lineman-jermayne-lole-out-for-season/68340745007/) is expected to miss the remainder of the season with an elbow injury. The Cardinals [won their meeting in 2021](https://www.news-journalonline.com/story/sports/college/football/2022/09/09/ncaa-football-ucf-knights-get-friday-rematch-louisville-cardinals/8003345001/) on a [late interception returned for a touchdown](https://www.courier-journal.com/story/sports/college/louisville/2021/09/17/louisville-football-3-takeaways-thriller-win-over-ucf/8315221002/). Isaiah Bowser's 2nd TD gives UCF lead] [John Rhys Plumlee sliced and diced Louisville with his legs, setting up Isaiah Bowser's second touchdown run of the night โ a 2-yarder to put the Knights ahead of Louisville, 14-7, early in the second quarter.] [It's the sixth multi-touchdown game in Bowser's career, and his second this season.] [Through three drives, UCF is averaging 9.8 yards per carry. Watch UCF alum Gabe Davis score the first touchdown of the 2022 NFL season](https://www.news-journalonline.com/story/sports/nfl/2022/09/08/gabe-davis-ucf-scores-first-touchdown-nfl-season-buffalo-bills-la-rams/8028709001/) [11:12 p.m. Tiyon Evans gives Louisville quick 7-0 lead over UCF] [Malik Cunningham and Louisville's offense methodically marched down the field and sucked the life out of the Bounce House on the game's opening drive.] [The Cardinals capped off a 10-play, 75-yard drive with Tiyon Evans' 7-yard TD run up the gut.] [Cunningham, who struggled in last week's loss at Syracuse, looked as dangerous as he did a year ago against UCF. Holding call erases John Rhys Plumlee's 75-yard TD pass] [For the second time tonight, UCF had a touchdown taken off the board due to a holding call.] [John Rhys Plumlee hit Javon Baker for a 75-yard score that would have put the Knights back in front, but Ryan Swoboda was guilty of a hold back around the line of scrimmage.] [Instead, UCF punted for the fifth straight drive. Louisville drains clock as field goal pushes lead to 6] [James Turner kicked a 35-yard field goal after Malik Cunningham again drove the Cardinals deep into UCF territory. [John Rhys Plumlee](https://www.news-journalonline.com/story/sports/college/football/2022/09/01/ucf-football-roster-quarterback-john-rhys-plumlee/7904540001/), a transfer from Ole Miss who threw for five touchdowns in his UCF debut against South Carolina State. [Cardinals](https://www.courier-journal.com/story/sports/college/louisville/2022/09/07/following-season-opening-loss-louisville-faces-fast-paced-ucf/65741913007/) to the Bounce House on Friday night. The Knights got the ball into the red zone, but a John Rhys Plumlee pass to Jaylon Griffin on fourth down was picked off with less than 3 minutes left. Louisville holds on to beat UCF 20-14] [John Rhys Plumlee drove the Knights down to the Louisville 37-yard line. [UCF Knights](https://ucfknights.com/sports/football) wanted to use it to exact some revenge.
Filed under: Football. Game #2 - UCF vs. Louisville. Preview, How to Watch. By Eric Lopez, TheSoTG ...
[Roy Philpott](https://twitter.com/RoyPhilpott), Andre Ware and [Paul Carcaterra](https://twitter.com/paulcarcaterra) [OddsShark](https://www.oddsshark.com/ncaaf/louisville-ucf-odds-september-9-2022-1635256)) at FBC Mortgage Stadium in a tremendous revenge game for last yearโs catastrophic loss in Kentucky.